منابع مشابه
Secretory Component in Human Mammary Carcinoma1
Since secretory component is thought to be a normal glandular epithelial cell product, surgical specimens from patients with mammary carcinoma, an epithelial cancer, were studied with antisera to human free secretory compo nent by indirect immunofluorescence microscopy. Normal breast tissue (10 cases) showed fluorescent epithelial cells confined to normal ducts. This was in marked contrast to i...
متن کاملCirculating secretory component in breast neoplasms.
The serum concentrations of IgAp and IgMr associated secretory component (SIgA and SIgM) of 98 patients with neoplasms of the breast were measured. Of the 56 patients with carcinomas, 11 had increased concentrations of circulating SIgM, which was almost twice as sensitive as SIgA as a marker for carcinoma. Concentrations of circulating SIgA and SIgM were independent of expression of secretory c...
متن کاملCleavage of membrane secretory component to soluble secretory component occurs on the cell surface of rat hepatocyte monolayers
Rat liver secretory component is synthesized as an integral membrane protein (mSC) and cleaved to an 80-kD soluble form (fSC) sometime during transcellular transport from the sinusoidal to the bile canalicular plasma membrane domain of hepatocytes. We have used 24-h monolayer cultures of rat hepatocytes to characterize the conversion of mSC to fSC. Cleavage of mSC in cultured hepatocytes is inh...
متن کاملInfluence of secretory immunoglobulin A and purified secretory component on dextran-sucrase activity of Streptococcus mutans.
The net stimulation of dextransucrase EC 2.4.1.5) activity from Streptococcus mutans HS6 by dextran, secretory immunoglobulin A, or secretory component was investigated. Approximately equal stimulation resulted from treatment with these three components.
متن کاملDemonstration of IgA and secretory component in human hepatocytes.
By the immunoperoxidase technique, immunoglobulin A(IgA) was demonstrated in 50% of human hepatocytes. The positively stained cells showed a tendency towards periportal clustering. Very few plasma cells were identified in the liver. The intrahepatocyte IgA is most probably derived from serum and on its way to the bile ducts. Secretory component (SC) had the same distribution as that of IgA. The...
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ژورنال
عنوان ژورنال: Immunity
سال: 2002
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(02)00341-2